The present work was performed to evaluate the effects of aqueous stem bark extract of Ailanthus excelsa (AESE) for anti-rheumatoid activity. Three doses of AESE (100, 200 & 400 mg/kg orally) were selected. Arthritis was induced by injecting 0.1 ml (0.1% w/v) of complete Freund’s adjuvant in subplanter region of left hind paw of Wistar albino rats. Different paramaters like paw edema (inflammation), body weight, ankle joint diameter, mechanical hyperalgesia, hematological studies, biochemical studies, spleen weight, radiological and histological analysis of bone damage were assessed in Freund’s adjuvant induced paw inflammatory model. Methotrexate (0.75 mg/kg, p.o) was the standard reference drug. Paw volume changes were estimated using plethysmometer and Randall-selieto apparatus used to determine the mechanical hyperalgesia. All dose levels of Ailanthus excelsa aqueous stem bark extract (AESE) showed significant and dose-dependent anti-rheumaroid effects compared to arthritic control group. Altogether these results suggest that the aqueous stem bark extract of Ailanthus excelsa could be considered as a potent anti-rheumatoid agent.
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